Cleanse your face with a mild cleanser and warm water. Use your fingertips rather than a sponge or washcloth. Blot your face dry with a clean towel. Wait 20 to 30 minutes before applying Tretinoin to your face to make sure your skin is completely dry. Using any kind of tretinoin cream on damp skin can increase your risk of side effects.
Use only a pea-sized amount for your entire face. Spread it evenly. Rub Tretinoin in thoroughly but gently, avoiding sensitive areas such as inside the nose, the lips or in or around the eyes. If Tretinoin accidentally gets on these parts of your face, rinse it off at once.
Be wary of skin sensitivity. An active ingredient in Tretinoin is acid that peels away layers of skin. The peeling process exposes the skin and causes it to burn more easily in the sun. The skin may become dry and itchy during the peeling process. Avoid exposing your face to the sun, wind and cold weather during the first six months you use Tretinoin, especially during the first few weeks of your treatment. Tretinoin makes your skin more susceptible to sunburn, so make sure to use a good sun protection. Use a sunscreen with a factor (SPF) of at least 15. Regardless if you're using Tretinoin to treat wrinkles, the daily use of sunscreen in your foundation or daily moisturizer is "critical" to protecting your skin from more extensive photoaging. Avoid tanning beds and sun lamps.
Tretinoin may contraindicate other topical or skin medications you're using and may be problematic for those with eczema or seborrheic dermatitis. Do not use Tretinoin if you are currently using any medications for your skin or have a history of skin infections or disease. Do not use Retin-A if you are pregnant, attempting to become pregnant or at high risk of pregnancy. Retinoids may cause fetal harm when administered to a pregnant woman. If you are breastfeeding, you can use Tretinoin but with caution as there are no studies relating to the transmission in human breast milk. Tretinoin cream and gel should not be used if you are allergic to any of its ingredients.